Mehnert, Angelika, Nicholl, Deborah, Pudas, Hanna, Martin, Monique and McGuire, Alistair (2012) Cost effectiveness of paliperidone palmitate versus risperidone long-acting injectable and olanzapine pamoate for the treatment of patients with schizophrenia in Sweden. Journal of Medical Economics, 15 (5). pp. 844-861. ISSN 1369-6998
Full text not available from this repository.Abstract
Objective: To model the cost effectiveness of paliperidone palmitate (paliperidone long-Acting injectable; PLAI), a new once-monthly long-Acting antipsychotic therapy, compared with risperidone long-Acting injectable (RLAI) and olanzapine pamoate (OLAI), in multi-episode patients (two or more relapses) with schizophrenia in Sweden. Methods: A Markov decision analytic model was developed to simulate the history of a cohort of multi-episode patients transitioning through different health states on a monthly basis over a 5-year time horizon from the perspective of the Swedish healthcare system. Therapeutic strategies consisted of starting treatment with RLAI (mean dose 37.5mg every 2 weeks), PLAI (mean dose 75mg equivalent (eq.) every month) or OLAI (150mg every 2 weeks or 300mg every 4 weeks). Probability of relapse, level of adherence, side-effects (extrapyramidal symptoms, tardive dyskinesia, weight gain and diabetes) and treatment discontinuation (switch) were derived from long-term observational data when feasible. Incremental cost-effectiveness outcomes, discounted at 3% annually, included cost per quality-Adjusted life-year (QALY) and cost per relapse avoided (expressed in 2009 Swedish Krona SEK). Results: Relative to RLAI and OLAI, PLAI is economically dominant: more effective (additional QALYs, less relapses) and less costly treatment option over a 5-year time horizon. The results were robust when tested in sensitivity analysis. Limitations: The impact of once-monthly treatment on adherence levels is not yet known, and not all variables that could impact on real-world outcomes and costs were included in this model. Conclusion: PLAI was cost saving from a Swedish payer perspective compared with RLAI and OLAI in the long-term treatment of multi-episode (two or more relapses) schizophrenia patients.
Item Type: | Article |
---|---|
Official URL: | http://www.jmejournal.com/ |
Additional Information: | © 2012 Informa UK |
Divisions: | Social Policy LSE Health |
Subjects: | H Social Sciences > HC Economic History and Conditions R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
JEL classification: | I - Health, Education, and Welfare > I1 - Health |
Date Deposited: | 11 Sep 2012 08:44 |
Last Modified: | 14 Aug 2024 03:12 |
URI: | http://eprints.lse.ac.uk/id/eprint/45764 |
Actions (login required)
![]() |
View Item |