A modeling framework for the analysis of the SARS-CoV2 transmission dynamics

Chatzilena, Anastasia, Demiris, Nikolas and Kalogeropoulos, Konstantinos ORCID: 0000-0002-0330-9105 (2024) A modeling framework for the analysis of the SARS-CoV2 transmission dynamics. Statistics in Medicine. ISSN 0277-6715

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Abstract

Despite the progress in medical data collection the actual burden of SARS-CoV-2 remains unknown due to under-ascertainment of cases. This was apparent in the acute phase of the pandemic and the use of reported deaths has been pointed out as a more reliable source of information, likely less prone to under-reporting. Since daily deaths occur from past infections weighted by their probability of death, one may infer the total number of infections accounting for their age distribution, using the data on reported deaths. We adopt this framework and assume that the dynamics generating the total number of infections can be described by a continuous time transmission model expressed through a system of nonlinear ordinary differential equations where the transmission rate is modeled as a diffusion process allowing to reveal both the effect of control strategies and the changes in individuals behavior. We develop this flexible Bayesian tool in Stan and study 3 pairs of European countries, estimating the time-varying reproduction number ( ) as well as the true cumulative number of infected individuals. As we estimate the true number of infections we offer a more accurate estimate of . We also provide an estimate of the daily reporting ratio and discuss the effects of changes in mobility and testing on the inferred quantities.

Item Type:	Article
Official URL:	https://onlinelibrary.wiley.com/journal/10970258
Additional Information:	© 2024 The Author(s)
Divisions:	Statistics
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine H Social Sciences > HA Statistics H Social Sciences > HV Social pathology. Social and public welfare. Criminology
Date Deposited:	16 Aug 2024 10:34
Last Modified:	16 Aug 2024 18:06
URI:	http://eprints.lse.ac.uk/id/eprint/124573

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