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Use of multicriteria decision analysis for assessing the benefit and risk of over-the-counter analgesics

Moore, Andrew, Crossley, Anne, Ng, Bernard, Phillips, Lawrence D., Sancak, Özgür and Rainsford, K.D. (2017) Use of multicriteria decision analysis for assessing the benefit and risk of over-the-counter analgesics. Journal of Pharmacy and Pharmacology, 69 (10). pp. 1364-1373. ISSN 2042-7158

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Abstract

Objectives : To test the ability of a multi-criteria decision analysis (MCDA) model to incorporate disparate data sources of varying quality along with clinical judgement in a benefit-risk assessment of six well-known pain-relief drugs. Methods: Six OTC analgesics were evaluated against three favourable effects and eight unfavourable effects by seven experts who specialise in the relief of pain, two in a two-day facilitated workshop whose input data and judgements were later peer-reviewed by five additional experts. Key findings: Ibuprofen salts & solubilised emerged with the best benefit-risk profile, followed by naproxen, ibuprofen acid, diclofenac, paracetamol, and aspirin. Conclusions: MCDA enabled participants to evaluate the OTC analgesics against a range of favourable and unfavourable effects in a group setting that enabled all issues to be openly aired and debated. The model was easily communicated and understood by the peer reviewers, so the model should be comprehensible to physicians, pharmacists, and other health professionals

Item Type: Article
Official URL: http://onlinelibrary.wiley.com/journal/10.1111/(IS...
Additional Information: © 2017 Royal Pharmaceutical Society
Divisions: Management
Subjects: H Social Sciences > HD Industries. Land use. Labor > HD28 Management. Industrial Management
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Sets: Departments > Management
Date Deposited: 05 Jun 2017 10:50
Last Modified: 20 Feb 2019 12:11
Funders: RBH Global Medical
URI: http://eprints.lse.ac.uk/id/eprint/79910

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