The effect of overcoming the digital divide on middle frontal gyrus atrophy in aging adults: large-scale retrospective magnetic resonance imaging cohort study

Li, Yumeng, Zhang, Xinyue, Sun, Jiaqing ORCID: 0000-0002-7896-5860, Zhang, Junying, Zhu, Aiqin, Li, Xin and Zhang, Zhanjun (2025) The effect of overcoming the digital divide on middle frontal gyrus atrophy in aging adults: large-scale retrospective magnetic resonance imaging cohort study. Journal of Medical Internet Research, 27. e73360-e73360. ISSN 1438-8871

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Abstract

Background The rapid integration of information technology into daily life has exacerbated the digital divide (DD), particularly among older adults, who often face barriers to technology adoption. Although prior research has linked technology use to cognitive benefits, the long-term neurostructural and cognitive consequences of the DD remain poorly understood. Objective The aim of this study is to use large-scale neuroimaging data to examine how the DD affects long-term brain structure and cognitive aging in older adults. It specifically investigates (1) structural and cognitive differences between older adults with and without DD engagement, (2) predictive relationships between group-distinctive brain regions and cognitive outcomes, and (3) longitudinal impacts of DD exposure on accelerated aging trajectories of neural substrates and cognitive functions. Methods The study included 1280 community-dwelling older adults (aged 65‐90 y) who completed comprehensive cognitive assessments and structural magnetic resonance imaging scans at baseline. Longitudinal data were available for 689 participants (mean follow-up 3.2 y). Participants were classified into the DD (n=640) and overcoming DD (n=640) groups using rigorous propensity score matching to control for age, education, gender, and baseline health conditions. A computational framework using the searchlight technique and cross-validation classification model investigated group differences in structural features and cognitive representation. The aging rate of each voxel’s structural feature was calculated to explore the long-term influence of the DD. Results The DD group showed significant deficits in executive function (t=4.75; P<.001; Cohen d=0.38) and processing speed (t=4.62; P<.001; Cohen d=0.37) compared to the overcoming DD group. Reduced gray matter volume in the DD group spanned the fusiform gyrus, hippocampus, parahippocampal gyrus, and superior temporal sulcus (false discovery rate–corrected P<.05). The computational framework identified the key structural substrates related to executive function and processing speed, excluding the ventro-orbitofrontal lobe (classification accuracy <0.6). Longitudinal findings highlighted the long-term impact of the DD. The DD group exhibited faster gray matter volume decline in the middle frontal gyrus (t=3.95 for the peak voxel in this cluster, false discovery rate–corrected P<.05), which mediated 17% of episodic memory decline (P=.02). Conclusions Older adults who overcome the DD demonstrate preserved gray matter structure and slower cognitive decline, particularly in frontotemporal regions critical for executive function. Our findings underscore that mobile digital interventions should be explored as potential cognitive decline prevention strategies.

Item Type:	Article
Additional Information:	© 2025 The Author(s)
Divisions:	Management
Date Deposited:	31 Jul 2025 18:03
Last Modified:	01 Aug 2025 03:15
URI:	http://eprints.lse.ac.uk/id/eprint/128974

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