Health state utility values in children and adolescents with disabilities: a systematic review

Kanya, Lucy ORCID: 0000-0003-4312-118X, Anokye, Nana, Alani, Ahmad Hecham ORCID: 0000-0001-6318-3017, Jayakumar, Nandini and Ryan, Jennifer M. (2024) Health state utility values in children and adolescents with disabilities: a systematic review. The Journal of Pediatrics: Clinical Practice. ISSN 2950-5410 (In Press)

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Abstract

Objectives To 1) provide a comprehensive summary of the methods used to obtain health state utility values (HSUVs) from children and adolescents with disabilities (CAD), 2) describe the administration and psychometric properties of these methods, and 3) report summary statistics for HSUVs obtained from each method. Study design English-language studies from MEDLINE (via PubMed), PsychInfo, Scopus, CINAHL Plus, EconLit, and Embase, were searched from inception to November 2024. Two reviewers independently screened titles, abstracts, and full-texts. Studies were included if they utilized direct or indirect methods to measure HSUVs, reported utilities and/or psychometric properties of these measures, and involved CAD aged 0-19 years. Two reviewers independently extracted study details including sample descriptors, instruments used and summary statistics. Studies quality was assessed using a novel tool derived from three validated checklists. Results Of the 3,541 screened articles, 31 met inclusion criteria. Only two studies used direct methods, such as Time Trade-Off (TTO), Visual Analogue Scale (VAS), Standard Gamble (SG), while 29 employed generic measures [e.g., EuroQol 5 Dimensions (EQ- 5D), Health Utilities Index 3 (HUI-3)] with diverse preference elicitation methods. Excessive dependence on proxy respondents was noted, and psychometric properties of generic measures were mixed. Conclusions Inconsistent HSUVs reporting and limited data availability is common. Reported HSUV summary statistics may be inaccurate if methodologies are unsuitable for the population. This review emphasizes the need for validated instruments to assess HSUVs in CAD.

Item Type:	Article
Additional Information:	© 2025 The Author(s)
Divisions:	LSE Health Health Policy
Date Deposited:	16 Jan 2025 17:21
Last Modified:	16 Jan 2025 17:27
URI:	http://eprints.lse.ac.uk/id/eprint/126907

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