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The economic cost of treatment-resistant depression in patients referred to a specialist service

McCrone, Paul and Rost, Felicitas and Koeser, Leonardo and Koutoufa, Iakovina and Stephanou, Stephanie and Knapp, Martin and Goldberg, David and Taylor, David and Fonagy, Peter (2017) The economic cost of treatment-resistant depression in patients referred to a specialist service. Journal of Mental Health. ISSN 0963-8237

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Identification Number: 10.1080/09638237.2017.1417562

Abstract

Background: Patients with treatment-resistant depression (TRD) suffer very significant morbidity and are at a disadvantage concerning optimal clinical management. There are high associated societal costs. Aims: A detailed analysis of health economic costs in the United Kingdom in a group manifesting a severe form of TRD in the 12 months before their participation in a major randomized controlled treatment trial. Methods: The sample consisted of 118 participants from the Tavistock Adult Depression Study. Recruitment was from primary care on the basis of current major depression disorder of at least 2 years’ duration and two failed treatment attempts. Service utilization was assessed based on self-report and general practitioner (GP) medical records. Generalized linear models were used to identify predictors of cost. Results: All participants used GP services. Use of other doctors and practice nurses was also high. The mean total societal cost was £22 124, 80% of which was due to lost work and care required of families. Level of general functioning was found to be the most consistent predictor of costs. Conclusions: Severe forms of TRD are associated with high costs in which unpaid care and lost work predominate. Treatments that improve functioning may reduce the large degree of burden.

Item Type: Article
Official URL: http://www.tandfonline.com/toc/ijmh20/current
Additional Information: © 2017 Informa UK Limited
Subjects: H Social Sciences > HN Social history and conditions. Social problems. Social reform
R Medicine > RA Public aspects of medicine
Sets: Departments > Health Policy
Date Deposited: 22 Feb 2018 14:50
Last Modified: 11 Apr 2018 15:04
URI: http://eprints.lse.ac.uk/id/eprint/86834

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