McCrone, Paul, Rost, Felicitas, Koeser, Leonardo, Koutoufa, Iakovina, Stephanou, Stephanie, Knapp, Martin 
ORCID: 0000-0003-1427-0215, Goldberg, David, Taylor, David and Fonagy, Peter
(2017)
The economic cost of treatment-resistant depression in patients referred to a specialist service.
Journal of Mental Health.
ISSN 0963-8237
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Abstract
Background: Patients with treatment-resistant depression (TRD) suffer very significant morbidity and are at a disadvantage concerning optimal clinical management. There are high associated societal costs. Aims: A detailed analysis of health economic costs in the United Kingdom in a group manifesting a severe form of TRD in the 12 months before their participation in a major randomized controlled treatment trial. Methods: The sample consisted of 118 participants from the Tavistock Adult Depression Study. Recruitment was from primary care on the basis of current major depression disorder of at least 2 years’ duration and two failed treatment attempts. Service utilization was assessed based on self-report and general practitioner (GP) medical records. Generalized linear models were used to identify predictors of cost. Results: All participants used GP services. Use of other doctors and practice nurses was also high. The mean total societal cost was £22 124, 80% of which was due to lost work and care required of families. Level of general functioning was found to be the most consistent predictor of costs. Conclusions: Severe forms of TRD are associated with high costs in which unpaid care and lost work predominate. Treatments that improve functioning may reduce the large degree of burden.
| Item Type: | Article |
|---|---|
| Official URL: | http://www.tandfonline.com/toc/ijmh20/current |
| Additional Information: | © 2017 Informa UK Limited |
| Divisions: | Health Policy |
| Subjects: | H Social Sciences > HN Social history and conditions. Social problems. Social reform R Medicine > RA Public aspects of medicine |
| Date Deposited: | 22 Feb 2018 14:50 |
| Last Modified: | 12 Dec 2024 01:37 |
| URI: | http://eprints.lse.ac.uk/id/eprint/86834 |
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