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Chromosomal disorders: estimating baseline birth prevalence and pregnancy outcomes worldwide

Moorthie, Sowmiya and Blencowe, Hannah and Darlison, Matthew W. and Gibbons, Stephen and Lawn, Joy E. and Mastroiacovo, Pierpaolo and Morris, Joan K. and Modell, Bernadette (2017) Chromosomal disorders: estimating baseline birth prevalence and pregnancy outcomes worldwide. Journal of Community Genetics. ISSN 1868-310X

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Identification Number: 10.1007/s12687-017-0336-2

Abstract

Chromosomal disorders, of which Down syndrome is the most common, can cause multi-domain disability. In addition, compared to the general population, there is a higher frequency of death before the age of five. In many settings, large gaps in data availability have hampered policy-making, programme priorities and resource allocation for these important conditions. We have developed methods, which overcome this lack of data and allow estimation of the burden of affected pregnancies and their outcomes in different settings worldwide. For example, the methods include a simple equation relating the percentage of mothers 35 and over to Down syndrome birth prevalence. The results obtained provide a starting point for consideration of services that can be implemented for the care and prevention of these disorders

Item Type: Article
Official URL: https://link.springer.com/journal/12687
Additional Information: © 2017 The Authors © CC BY 4.0
Subjects: H Social Sciences > HQ The family. Marriage. Woman
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Sets: Departments > Geography and Environment
Date Deposited: 12 Jan 2018 17:25
Last Modified: 15 Jan 2018 11:04
URI: http://eprints.lse.ac.uk/id/eprint/86436

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