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Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps

Simpkin, Victoria L. and Renwick, Matthew J. and Kelly, Ruth and Mossialos, Elias (2017) Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps. The Journal of Antibiotics, 70 (12). pp. 1087-1096. ISSN 0021-8820

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Identification Number: 10.1038/ja.2017.124


Political momentum and funding for combatting antimicrobial resistance (AMR) continues to build. Numerous major international and national initiatives aimed at financially incentivising the research and development (R&D) of antibiotics have been implemented. However, it remains unclear how to effectively strengthen the current set of incentive programmes to further accelerate antibiotic innovation. Based on a literature review and expert input, this study first identifies and assesses the major international, European Union, US and UK antibiotic R&D funding programmes. These programmes are then evaluated across market and public health criteria necessary for comprehensively improving the antibiotic market. The current set of incentive programmes are an important initial step to improving the economic feasibility of antibiotic development. However, there appears to be a lack of global coordination across all initiatives, which risks duplicating efforts, leaving funding gaps in the value chain and overlooking important AMR goals. This study finds that incentive programmes are overly committed to early-stage push funding of basic science and preclinical research, while there is limited late-stage push funding of clinical development. Moreover, there are almost no pull incentives to facilitate transition of antibiotic products from early clinical phases to commercialisation, focus developer concentration on the highest priority antibiotics and attract large pharmaceutical companies to invest in the market. Finally, it seems that antibiotic sustainability and patient access requirements are poorly integrated into the array of incentive mechanisms

Item Type: Article
Official URL:
Additional Information: © 2017 The Authors © CC BY-NC-SA 4.0
Subjects: H Social Sciences > HJ Public Finance
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Sets: Research centres and groups > LSE Health
Date Deposited: 12 Jan 2018 16:30
Last Modified: 12 Jan 2018 16:30

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