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The effect of midlife risk factors on dementia in older age

Personal Social Services Research Unit, LSE (2017) The effect of midlife risk factors on dementia in older age. . Public Health England, London, UK.

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Public Health England (PHE) commissioned the Personal Social Services Research Unit (PSSRU) at the London School of Economics and Political Science (LSE) to conduct a study on primary prevention of dementia. The aim of the study is to provide information to assist commissioners to make decisions about prioritisation of primary prevention measures relevant to dementia. This report presents findings from a focused review of evidence, which formed a substantial part of the overall study. The review covers all types of dementia and in all age groups, subject to the availability of evidence. It focuses on recent literature on the relationship between changes in risk factor behaviours or conditions in midlife (ages 40 to 64) and onset of dementia later in life. The risk factors considered comprise: smoking, excessive drinking, high blood pressure, lack of physical activity and obesity, diabetes, depression and other common mental health conditions, social isolation and loneliness, and lifelong learning and cognitive stimulation. For the risk factors which were considered in a recent systematic review (Norton et al. 2014) we searched for more recent systematic reviews or primary empirical studies published for any possible new evidence or more comprehensive reviews. For the risk factors not considered in that systematic review, we searched for relevant papers in the recent NICE review on midlife risk factors and dementia in older age (Lafortune et al., 2016; Lafortune, Kelly, and Cowan, 2014) and when necessary, conducted additional searches for papers published since 2000...

Item Type: Monograph (Report)
Official URL:
Additional Information: © 2017 Crown copyright © Open Government Licence v3.0
Divisions: Personal Social Services Research Unit
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Sets: Research centres and groups > Personal Social Services Research Unit (PSSRU)
Date Deposited: 16 Aug 2017 14:10
Last Modified: 08 Jan 2021 01:26

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