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Clinical and pathologic remission of pediatric ulcerative colitis with serum-derived bovine immunoglobulin added to the standard treatment regimen

Soriano, Rachelle A. and Ramos-Soriano, Asuncion G. (2017) Clinical and pathologic remission of pediatric ulcerative colitis with serum-derived bovine immunoglobulin added to the standard treatment regimen. Case Reports in Gastroenterology, 11 (2). pp. 335-343. ISSN 1662-0631

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Identification Number: 10.1159/000475923

Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is particularly troublesome for pediatric patients, as current therapeutic options consist of biologic agents and steroids which alter the immune response and have the harmful side effect of leaving the patient more susceptible to opportunistic infections and eventual surgery. Another option for therapy exists in the form of serum-derived bovine immunoglobulin/protein isolate (SBI), the key ingredient in a medical food, EnteraGam®. The FDA has reviewed the safety of SBI and issued a no challenge letter to the generally recognized as safe (GRAS) findings for this medical food. The product also has no known food or drug interactions, no significant adverse effects, and no contraindications, save for beef allergy. SBI has been shown to induce clinical remission in adult populations and to decrease markers of inflammation in pediatric patients. Here, we present a detailed case of pediatric UC, including documentation of mucosal healing and decrease in pediatric UC activity index in a difficult to treat pediatric patient, after the addition of SBI to this patient’s treatment regimen.

Item Type: Article
Official URL: https://www.karger.com/Journal/Home/232833
Additional Information: © 2017 The Authors
Divisions: Social Policy
Subjects: R Medicine > RJ Pediatrics
Sets: Departments > Social Policy
Date Deposited: 06 Jul 2017 10:03
Last Modified: 20 Mar 2019 03:16
URI: http://eprints.lse.ac.uk/id/eprint/83216

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