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Systematic review and meta-analysis of hepatitis C virus infection and HIV viral load: new insights into epidemiologic synergy

Petersdorf, Nicholas, Ross, Jennifer M., Weiss, Helen A., Barnabas, Ruanne V. and Wasserheit, Judith N. (2016) Systematic review and meta-analysis of hepatitis C virus infection and HIV viral load: new insights into epidemiologic synergy. Journal of the International AIDS Society, 19 (20944). pp. 1-8. ISSN 1758-2652

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Identification Number: 10.7448/IAS.19.1.20944

Abstract

Introduction: Hepatitis C virus (HCV) and HIV infection frequently co-occur due to shared transmission routes. Co-infection is associated with higher HCV viral load (VL), but less is known about the effect of HCV infection on HIV VL and risk of onward transmission. Methods: We undertook a systematic review comparing 1) HIV VL among ART-naı¨ve, HCV co-infected individuals versus HIV mono-infected individuals and 2) HIV VL among treated versus untreated HCV co-infected individuals. We performed a randomeffects meta-analysis and quantified heterogeneity using the I 2 statistic. We followed Cochrane Collaboration guidelines in conducting our review and PRISMA guidelines in reporting results. Results and discussion: We screened 3925 articles and identified 17 relevant publications. A meta-analysis found no evidence of increased HIV VL associated with HCV co-infection or between HIV VL and HCV treatment with pegylated interferon-alpha-2a/b and ribavirin. Conclusions: This finding is in contrast to the substantial increases in HIV VL observed with several other systemic infections. It presents opportunities to elucidate the biological pathways that underpin epidemiological synergy in HIV co-infections and may enable prediction of which co-infections are most important to epidemic control.

Item Type: Article
Official URL: http://www.jiasociety.org/index.php/jias
Additional Information: © The Authors © CC BY 3.0
Divisions: LSE Health
Subjects: R Medicine > RA Public aspects of medicine
Sets: Research centres and groups > LSE Health
Date Deposited: 07 Apr 2017 15:45
Last Modified: 19 Nov 2019 12:40
Projects: T32AI007140, MR/K012126/1
Funders: National Institutes of Health, Medical Research Council
URI: http://eprints.lse.ac.uk/id/eprint/73065

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