Cookies?
Library Header Image
LSE Research Online LSE Library Services

Cluster randomized controlled trial

Forster, Anne and Young, John and Chapman, Katie and Nixon, Jane and Patel, Anita and Holloway, Ivana and Mellish, Kirste and Anwar, Shamaila and Breen, Rachel and Knapp, Martin and Murray, Jenni and Farrin, Amanda (2015) Cluster randomized controlled trial. Stroke, 46 (8). pp. 2212-2219. ISSN 0039-2499

Full text not available from this repository.

Identification Number: 10.1161/STROKEAHA.115.008585

Abstract

Background and Purpose—We developed a new postdischarge system of care comprising a structured assessment covering longer-term problems experienced by patients with stroke and their carers, linked to evidence-based treatment algorithms and reference guides (the longer-term stroke care system of care) to address the poor longer-term recovery experienced by many patients with stroke. Methods—A pragmatic, multicentre, cluster randomized controlled trial of this system of care. Eligible patients referred to community-based Stroke Care Coordinators were randomized to receive the new system of care or usual practice. The primary outcome was improved patient psychological well-being (General Health Questionnaire-12) at 6 months; secondary outcomes included functional outcomes for patients, carer outcomes, and cost-effectiveness. Follow-up was through self-completed postal questionnaires at 6 and 12 months. Results—Thirty-two stroke services were randomized (29 participated); 800 patients (399 control; 401 intervention) and 208 carers (100 control; 108 intervention) were recruited. In intention to treat analysis, the adjusted difference in patient General Health Questionnaire-12 mean scores at 6 months was −0.6 points (95% confidence interval, −1.8 to 0.7; P=0.394) indicating no evidence of statistically significant difference between the groups. Costs of Stroke Care Coordinator inputs, total health and social care costs, and quality-adjusted life year gains at 6 months, 12 months, and over the year were similar between the groups. Conclusions—This robust trial demonstrated no benefit in clinical or cost-effectiveness outcomes associated with the new system of care compared with usual Stroke Care Coordinator practice.

Item Type: Article
Official URL: http://stroke.ahajournals.org/
Additional Information: © 2015 Bradford Teaching Hospitals NHS Foundation Trust
Divisions: Personal Social Services Research Unit
Subjects: R Medicine > RA Public aspects of medicine
Sets: Research centres and groups > Personal Social Services Research Unit (PSSRU)
Date Deposited: 11 Sep 2015 14:49
Last Modified: 11 Sep 2015 14:49
URI: http://eprints.lse.ac.uk/id/eprint/63519

Actions (login required)

View Item View Item