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The critical role of observational evidence in comparative effectiveness research

Fleurence, Rachel L., Naci, Huseyin and Jansen, Jeroen P. (2010) The critical role of observational evidence in comparative effectiveness research. Health Affairs, 29 (10). pp. 1826-1833. ISSN 0278-2715

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Identification Number: 10.1377/hlthaff.2010.0630


Although not the gold standard of clinical research, observational studies can play a central role as the nation’s health care system embraces comparative effectiveness research. Investigators generally prefer randomized trials to observational studies because the former are less subject to bias. Randomized studies, however, often don’t represent real-world patient populations, while observational studies can offer quicker results and the opportunity to investigate large numbers of interventions and outcomes among diverse populations—sometimes at lower costs. But some decisions based on observational studies have turned out to be wrong. We recommend that researchers adopt a “body of evidence” approach that includes both randomized and observational evidence.

Item Type: Article
Official URL:
Additional Information: © 2010 Project HOPE - The People-to-People Health Fouhdation
Divisions: LSE Health
Subjects: R Medicine > RA Public aspects of medicine
Date Deposited: 04 Feb 2014 10:07
Last Modified: 02 Jul 2024 05:06

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