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Therapeutic substitution post-patent expiry: the cases of ace inhibitors and proton pump inhibitors

Vandoros, Sotiris (2014) Therapeutic substitution post-patent expiry: the cases of ace inhibitors and proton pump inhibitors. Health Economics, 23 (5). pp. 621-630. ISSN 1057-9230

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Abstract

This paper examines whether there is a switch in total (originator and generic) consumption after generic entry from molecules that face generic competition towards other molecules of the same class, which are still in-patent. Data from six European countries for the time period 1991 to 2006 are used to study the cases of angiotensin-converting enzyme inhibitors and proton pump inhibitors. Empirical evidence shows that patent expiry of captopril and enalapril led to a switch in total (off-patent originator and generic) consumption towards other in-patent angiotensin-converting enzyme inhibitors, whereas patent expiry of omeprazole led to a switch in consumption towards other proton pump inhibitors. This phenomenon makes generic policies ineffective and results in an increase in pharmaceutical expenditure due to the absence of generic alternatives in the market of in-patent molecules.

Item Type: Article
Official URL: http://onlinelibrary.wiley.com/journal/10.1002/(IS...
Additional Information: © 2013 John Wiley & Sons, Ltd.
Library of Congress subject classification: R Medicine > RM Therapeutics. Pharmacology
T Technology > T Technology (General) > T201 Patents. Trademarks
Sets: Research centres and groups > LSE Health
Rights: http://www.lse.ac.uk/library/usingTheLibrary/academicSupport/OA/depositYourResearch.aspx
Funders: Suntory and Toyota International Centres for Economics and Related Disciplines
Date Deposited: 07 Jun 2013 15:23
URL: http://eprints.lse.ac.uk/50695/

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