Atkinson, Anthony C. (2012) Optimum experimental designs for choosing between competitive and non competitive models of enzyme inhibition. Communications in Statistics - Theory and Methods, 41 (13-14). pp. 2283-2296. ISSN 0361-0926
Full text not available from this repository.Abstract
In the study of the inhibition of enzyme reactions the Michaelis-Menten model is extended to include two experimental variables and three or more parameters. We combine the three-parameter models for competitive and non competitive inhibition in a four-parameter model and use optimum design theory to find D-and Ds-optimum designs for discriminating between the models. These designs are compared with compound T-optimum designs which provide the most powerful tests for discrimination between models. A single design is found with high discrimination efficiency whichever model is true.
| Item Type: | Article |
|---|---|
| Official URL: | http://www.tandfonline.com/action/aboutThisJournal... |
| Additional Information: | © 2012 Taylor and Francis Group, LLC. |
| Divisions: | Statistics |
| Subjects: | H Social Sciences > HA Statistics |
| Date Deposited: | 02 Jul 2012 13:38 |
| Last Modified: | 12 Dec 2024 00:09 |
| URI: | http://eprints.lse.ac.uk/id/eprint/44571 |
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