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The permeability parameter of the outer membrane of pseudomonas aeruginosa Varies with the concentration of a test substrate, cephalosporin C

Hewinson, R. Glyn, Lane, David C., Slack, Mary P. E. and Nichols, Wright W. (1986) The permeability parameter of the outer membrane of pseudomonas aeruginosa Varies with the concentration of a test substrate, cephalosporin C. Microbiology, 132 (1). pp. 27-33. ISSN 1350-0872

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Abstract

The permeability parameter (C) for the movement of cephalosporin C across the outer membrane of Pseudomonas aeruginosa was measured using the widely accepted method of Zimmermann & Rosselet. In one experiment, the value of C varied continuously from 4·2 to 10·8 cm3 min-1 (mg dry wt cells)-1 over a range of concentrations of the test substrate, cephalosporin C, from 50 to 5 μm. Dependence of C on the concentration of test substrate was still observed when the effect of a possible electric potential difference across the outer membrane was corrected for. In quantitative studies of β-lactam permeation the dependence of C on the concentration of β-lactam should be taken into account.

Item Type: Article
Official URL: http://mic.sgmjournals.org/
Additional Information: © 1986 Society for General Microbiology
Library of Congress subject classification: Q Science > QR Microbiology
Sets: Departments > Management
Research centres and groups > Managerial Economics and Strategy Group
Research centres and groups > Management Science Group
Rights: http://www.lse.ac.uk/library/usingTheLibrary/academicSupport/OA/depositYourResearch.aspx
Date Deposited: 14 Jun 2012 13:57
URL: http://eprints.lse.ac.uk/44357/

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