Hewinson, R. Glyn, Lane, David C., Slack, Mary P. E. and Nichols, Wright W. (1986) The permeability parameter of the outer membrane of pseudomonas aeruginosa Varies with the concentration of a test substrate, cephalosporin C. Microbiology, 132 (1). pp. 27-33. ISSN 1350-0872
Abstract
The permeability parameter (C) for the movement of cephalosporin C across the outer membrane of Pseudomonas aeruginosa was measured using the widely accepted method of Zimmermann & Rosselet. In one experiment, the value of C varied continuously from 4·2 to 10·8 cm3 min-1 (mg dry wt cells)-1 over a range of concentrations of the test substrate, cephalosporin C, from 50 to 5 μm. Dependence of C on the concentration of test substrate was still observed when the effect of a possible electric potential difference across the outer membrane was corrected for. In quantitative studies of β-lactam permeation the dependence of C on the concentration of β-lactam should be taken into account.
| Item Type: | Article |
|---|---|
| Official URL: | http://mic.sgmjournals.org/ |
| Additional Information: | © 1986 Society for General Microbiology |
| Library of Congress subject classification: | Q Science > QR Microbiology |
| Sets: | Departments > Management Research centres and groups > Managerial Economics and Strategy Group Research centres and groups > Management Science Group |
| Rights: | http://www.lse.ac.uk/library/rights/LSERO.htm |
| URL: | http://eprints.lse.ac.uk/44357/ |
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