Kabatereine, Narcis B., Brooker, Simon, Koukounari, Artemis, Kazibwe, Francis, Tukahebwa, Edridah, Fleming, Fiona, Zhang, Yaobi, Webster, Joanne P., Stothard, J. Russell and Fenwick, Alan (2007) Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren. Bulletin of the World Health Organization, 85 (2). pp. 85-160. ISSN 0042-9686
Full text not available from this repository.Abstract
Objective We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003. Methods We conducted longitudinal surveys on infection status, haemoglobin concentration and clinical morbidity in 1871 randomly selected schoolchildren from 37 schools in eight districts across Uganda at three time points — before chemotherapy and after one year and two years of annual mass chemotherapy. Findings Mass treatment with praziquantel and albendazole led to a significant decrease in the intensity of Schistosoma mansoni — 70% (95% confidence interval (CI): 66–73%) after one year and 82% (95% CI: 80–85%) after two years of treatment. Intensity of hookworm infection also decreased (75% and 93%; unadjusted). There was a significant increase in haemoglobin concentration after one (0.135 g/dL (95% CI: 0.126–0.144)) and two years (0.303 g/dL (95% CI: 0.293–0.312)) of treatment, and a significant decrease in signs of early clinical morbidity. The impact of intervention on S. mansoni prevalence and intensity was similar to that predicted by mathematical models of the impact of chemotherapy on human schistosomiasis. Improvements in haemoglobin concentration were greatest among children who were anaemic or harbouring heavy S. mansoni infection at baseline. Conclusion Anthelmintic treatment delivered as part of a national helminth control programme can decrease infection and morbidity among schoolchildren and improve haemoglobin concentration.
| Item Type: | Article |
|---|---|
| Official URL: | http://www.who.int/bulletin/en/ |
| Additional Information: | © 2007 World Health Organization |
| Divisions: | Statistics |
| Subjects: | D History General and Old World > DT Africa R Medicine > RA Public aspects of medicine |
| Date Deposited: | 01 Aug 2011 13:39 |
| Last Modified: | 05 Nov 2024 08:45 |
| URI: | http://eprints.lse.ac.uk/id/eprint/37721 |
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