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Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample

De Neve, Jan-Emmanuel (2011) Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample. Journal of Human Genetics, 56 (6). pp. 456-459. ISSN 1434-5161

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Abstract

Variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is a promising candidate for better understanding individual heterogeneity in subjective well-being or happiness, as measured by life satisfaction. This functional polymorphism has previously been associated with mental health and selective processing of positive and negative emotional stimuli. A case-control association study on a representative sample of Americans (N=2574) finds that individuals with the transcriptionally more efficient version of the serotonin transporter gene, report significantly higher levels of life satisfaction (P=0.01). This new finding may help explain the important genetic component of the individual baseline levels of happiness.

Item Type: Article
Official URL: http://www.nature.com/jhg/index.html
Additional Information: © 2011 The Japan Society of Human Genetics
Library of Congress subject classification: B Philosophy. Psychology. Religion > BJ Ethics
Q Science > QH Natural history > QH426 Genetics
Sets: Departments > Government
Rights: http://www.lse.ac.uk/library/usingTheLibrary/academicSupport/OA/depositYourResearch.aspx
Date Deposited: 20 Jul 2011 10:43
URL: http://eprints.lse.ac.uk/37525/

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