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Assessing nonsuperiority, noninferiority, or equivalence when comparing two regression models over a restricted covariate region

Liu, W., Bretz, F., Hayter, A. J. and Wynn, Henry (2009) Assessing nonsuperiority, noninferiority, or equivalence when comparing two regression models over a restricted covariate region. Biometrics, 65 (4). pp. 1279-1287. ISSN 1541-0420

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Abstract

In many scientific problems the purpose of the comparison of two regression models, which describe the relationship between a same response variable and several same covariates for two different groups, is to demonstrate that one model is no higher than the other by a negligible amount, or to demonstrate that the models have only negligible differences and so they can be regarded as describing practically the same relationship between the response variable and the covariates. In this article, methods based on one-sided pointwise confidence bands are proposed for assessing the nonsuperiority of one model to the other and for assessing the equivalence of two regression models. Examples from QT/QTc study and from drug stability study are used to illustrate the methods.

Item Type: Article
Official URL: http://www3.interscience.wiley.com/journal/1185383...
Additional Information: © 2009 by John Wiley & Sons, Inc.,
Library of Congress subject classification: H Social Sciences > HA Statistics
Sets: Research centres and groups > Decision Support and Risk Group (DSRG)
Rights: http://www.lse.ac.uk/library/usingTheLibrary/academicSupport/OA/depositYourResearch.aspx
Identification Number: UT ISI:000272128200030
Date Deposited: 29 Jan 2010 11:52
URL: http://eprints.lse.ac.uk/26727/

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