Berndt, Ernst R., Glennerster, Rachel, Kremer, Michael R., Lee, Jean, Levine, Ruth, Weizsäcker, Georg and Williams, Heidi (2005) Advanced purchase commitments for a malaria vaccine: estimating costs and effectiveness. PEPP (2). Suntory and Toyota International Centres for Economics and Related Disciplines, London, UK.
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Abstract
To overcome the problem of insufficient research and development (R&D) on vaccines for diseases concentrated in low-income countries, sponsors could commit to purchase viable vaccines if and when they are developed. One or more sponsors would commit to a minimum price that would be paid per person immunized for an eligible product, up to a certain number of individuals immunized. For additional purchases, the price would eventually drop to short-run marginal cost. If no suitable product were developed, no payments would be made. We estimate the offer size which would make the revenues from R&D investments on a malaria vaccine similar to revenues realized from investments in typical existing commercial pharmaceutical products, as well as the degree to which various contract models and assumptions would affect the cost-effectiveness of such a commitment for the case of a malaria vaccine. Under conservative assumptions, we document that the intervention would be highly cost-effective from a public health perspective. Sensitivity analyses suggest most characteristics of a hypothetical malaria vaccine would have little effect on the cost-effectiveness, but that the duration of protection against malaria conferred by a vaccine strongly affects potential cost-effectiveness. Readers can conduct their own sensitivity analyses employing a web-based spreadsheet tool.
| Item Type: | Monograph (Discussion Paper) |
|---|---|
| Official URL: | http://sticerd.lse.ac.uk |
| Additional Information: | © 2005 the authors |
| Divisions: | STICERD Economics |
| Subjects: | R Medicine > RA Public aspects of medicine |
| JEL classification: | O - Economic Development, Technological Change, and Growth > O3 - Technological Change; Research and Development > O31 - Innovation and Invention: Processes and Incentives O - Economic Development, Technological Change, and Growth > O1 - Economic Development > O19 - International Linkages to Development; Role of International Organizations O - Economic Development, Technological Change, and Growth > O3 - Technological Change; Research and Development > O38 - Government Policy I - Health, Education, and Welfare > I1 - Health > I18 - Government Policy; Regulation; Public Health |
| Date Deposited: | 11 Jul 2008 11:24 |
| Last Modified: | 13 Sep 2024 19:55 |
| URI: | http://eprints.lse.ac.uk/id/eprint/19301 |
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