Kwon, Joseph, Schoutens, Lisanne, Burden, Mitchell, Colam, Charlotte, Zhao, Sihao, Nezafat Maldonado, Behrouz, Blundell, Elizabeth, Krywonos, Anastasia, Jiang, Jingjing, Karagiannidou, Maria ORCID: 0000-0001-6996-4332, Jindra, Christoph, Vaci, Nemanja, Roberts, Nia, Wittenberg, Raphael
ORCID: 0000-0003-3096-2721, Knapp, Martin
ORCID: 0000-0003-1427-0215, Sanchez, Amparo Yovanna Castro, Roncancio-Diaz, Emilse, Potashman, Michele H, Thompson, Robin, Handels, Ron, Wolstenholme, Jane, Gray, Alastair M. and Landeiro, Filipa
(2025)
Systematic review of health economic models for assessment and diagnosis of dementia.
Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging, 1 (3).
ISSN 2997-3805
![]() |
Text (Alzheimer s Dementia Behavior Socioeconomics of Aging - 2025 - Kwon - Systematic review of health economic models for)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) |
Abstract
INTRODUCTION: Timely diagnosis of dementia is a public health priority to enable risk modification and treatment access. This study systematically identifies and critically appraises health economic models of dementia assessment and diagnosis. METHODS: Inclusion criteria were: any dementia stage; evaluated strategy(ies) for initial assessment/diagnosis of dementia; health economic evaluation using decision modeling. Ten databases were searched for 2000–2024. Philips checklist was applied for quality assessment. Narrative synthesis appraised methodological features and issued decision‐making recommendations. RESULTS: Thirty‐two studies were included. Six evaluated cerebrospinal fluid (CSF); 11 neuroimaging including amyloid‐targeting positron emission tomography; three blood‐based biomarkers; two genetic testing; and 10 early assessment/diagnosis strategies. Methodological limitations included non‐consideration of capacity constraints. Decision‐making recommendations generally affirmed current clinical guidelines: for example, CSF to confirm Alzheimer's disease is cost‐effective (incremental cost‐effectiveness ratio of £10,150 per quality‐adjusted life‐year gained vs. no use). DISCUSSION: Methodological appraisal and decision‐making recommendations should assist model development and evidence‐based dementia diagnosis.
Item Type: | Article |
---|---|
Additional Information: | © 2025 The Author(s) |
Divisions: | Care Policy and Evaluation Centre |
Subjects: | R Medicine > RA Public aspects of medicine |
Date Deposited: | 30 Jun 2025 14:33 |
Last Modified: | 18 Jul 2025 14:51 |
URI: | http://eprints.lse.ac.uk/id/eprint/128590 |
Actions (login required)
![]() |
View Item |