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Associations between HIV stigma and health-related quality-of-life among people living with HIV: cross-sectional analysis of data from HPTN 071 (PopART)

Hall, Emily, Davis, Katherine, Ohrnberger, Julius, Pickles, Michael, Gregson, Simon, Thomas, Ranjeeta ORCID: 0000-0002-0947-4574, Hargreaves, James R., Pliakas, Triantafyllos, Bwalya, Justin, Dunbar, Rory, Mainga, Tila, Shanaube, Kwame, Hoddinott, Graeme, Bond, Virginia, Bock, Peter, Ayles, Helen, Stangl, Anne L., Donnell, Deborah, Hayes, Richard, Fidler, Sarah and Hauck, Katharina (2024) Associations between HIV stigma and health-related quality-of-life among people living with HIV: cross-sectional analysis of data from HPTN 071 (PopART). Scientific Reports, 14 (1). ISSN 2045-2322

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Identification Number: 10.1038/s41598-024-63216-3

Abstract

People living with HIV (PLHIV) report lower health-related quality-of-life (HRQoL) than HIV-negative people. HIV stigma may contribute to this. We explored the association between HIV stigma and HRQoL among PLHIV. We used cross-sectional data from 3991 randomly selected PLHIV who were surveyed in 2017–2018 for HPTN 071 (PopART), a cluster randomised trial in Zambia and South Africa. Participants were 18–44 years, had laboratory-confirmed HIV infection, and knew their status. HRQoL was measured using the EuroQol-5-dimensions-5-levels (EQ-5D-5L) questionnaire. Stigma outcomes included: internalised stigma, stigma experienced in the community, and stigma experienced in healthcare settings. Associations were examined using logistic regression. Participants who had experienced community stigma (n = 693/3991) had higher odds of reporting problems in at least one HRQoL domain, compared to those who had not (adjusted odds ratio, aOR: 1.51, 95% confidence interval, 95% Cl: 1.16–1.98, p = 0.002). Having experienced internalised stigma was also associated with reporting problems in at least one HRQoL domain (n = 552/3991, aOR: 1.98, 95% CI: 1.54–2.54, p < 0.001). However, having experienced stigma in a healthcare setting was less common (n = 158/3991) and not associated with HRQoL (aOR: 1.04, 95% CI: 0.68–1.58, p = 0.850). A stronger focus on interventions for internalised stigma and stigma experienced in the community is required.

Item Type: Article
Official URL: https://www.nature.com/srep/
Additional Information: © 2024 The Author(s)
Divisions: Health Policy
Subjects: R Medicine > RA Public aspects of medicine
B Philosophy. Psychology. Religion > BF Psychology
Date Deposited: 24 Jun 2024 11:15
Last Modified: 12 Dec 2024 04:20
URI: http://eprints.lse.ac.uk/id/eprint/123953

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