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A systematic review of value criteria for next-generation sequencing/ comprehensive genomic profiling to inform value framework development

Augustovski, Federico, Colaci, Carla, Mills, Mackenzie, Chávez, Danitza, Argento, Fernando, Alfie, Verónica, Pichon Riviere, Andrés, Kanavos, Panos ORCID: 0000-0001-9518-3089 and Alcaraz, Andrea (2024) A systematic review of value criteria for next-generation sequencing/ comprehensive genomic profiling to inform value framework development. Value in Health, 27 (5). 670 - 685. ISSN 1098-3015

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Identification Number: 10.1016/j.jval.2024.02.002


Objectives: To comprehensively identify and map an exhaustive list of value criteria for the assessment of next-generation sequencing/comprehensive genomic profiling (NGS/CGP), to be used as an aid in decision making. Methods: We conducted a systematic review to identify existing value frameworks (VFs) applicable to any type of healthcare technology. VFs and criteria were mapped to a previously published Latin American (LA) VF to harmonize definitions and identify additional criteria and or subcriteria. Based on this analysis, we extracted a comprehensive, evidence-based list of criteria and subcriteria to be considered in the design of a NGS/CGP VF. Results: A total of 42 additional VFs were compared with the LA VF, 88% were developed in high-income countries, 30% targeted genomic testing, and 16% specifically targeted oncology. A total of 242 criteria and subcriteria were extracted; 227 (94%) were fully/partially included in the LA VF; and 15 (6%) were new. Clinical benefit and economic aspects were the most common criteria. VFs oriented to genomic testing showed significant overlap with other VFs. Considering all criteria and subcriteria, a total of 18 criteria and 36 individual subcriteria were identified. Conclusions: Our study provides an evidence-based set of criteria and subcriteria for healthcare decision making useful for NGS/CGP as well as other health technologies. The resulting list can be beneficial to inform decision making and will serve as a foundation to co-create a multistakeholder NGS/CGP VF that is aligned with the needs and values of health systems and could help to improve patient access to high-value technologies.

Item Type: Article
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Additional Information: © 2024 The Author(s)
Divisions: Health Policy
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Date Deposited: 18 Mar 2024 15:57
Last Modified: 18 Jul 2024 17:30

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