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Challenges and opportunities for incentivising antibiotic research and development in Europe

Anderson, Michael ORCID: 0000-0002-8454-4640, Panteli, Dimitra, van Kessel, Robin, Ljungqvist, Gunnar, Colombo, Francesca and Mossialos, Elias ORCID: 0000-0001-8664-9297 (2023) Challenges and opportunities for incentivising antibiotic research and development in Europe. The Lancet Regional Health - Europe, 33. ISSN 2666-7762

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Identification Number: 10.1016/j.lanepe.2023.100705


Antimicrobial, and particularly antibiotic resistance are one of the world's biggest challenges today, and urgent action is needed to reinvigorate the antibiotic development pipeline. To inform policy discussions during and after the 2023 Swedish Presidency of the Council of the European Union, we critically appraise incentive options recently proposed by the European Commission, and member states, and consider what has been achieved over the last two decades in relation to antibiotic research and development. While several new antibiotics have achieved regulatory approval in recent years, almost none have innovative characteristics such as new chemical classes or novel mechanisms of action. We consider four incentive options to incentivise research and development of new antibiotics, including subscription payments, market entry rewards, transferable exclusivity extensions, and milestone payments. While each option has advantages and drawbacks, a combination of incentives may be required and continued investment is needed by the EU in push incentives, such as direct funding and grants, to incentivise drug discovery and preclinical stages of development. The EU must also coordinate with international initiatives and support access to new and pre-existing antibiotics in LMICs through platforms such as the WHO, and G7 and G20 group of countries.

Item Type: Article
Official URL:
Additional Information: © 2023 The Author(s)
Divisions: Health Policy
European Observatory on Health Systems
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Date Deposited: 09 Aug 2023 09:33
Last Modified: 23 Feb 2024 22:15

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