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Randomizing a clinical trial in neuro-degenerative disease

Atkinson, Anthony C., Duarte, Belmiro P.M., Pedrosa, David and van Munster, Marlena (2023) Randomizing a clinical trial in neuro-degenerative disease. Contemporary Clinical Trials Communications, 33. ISSN 2451-8654

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Identification Number: 10.1016/j.conctc.2023.101140


The paper studies randomization rules for a sequential two-treatment, two-site clinical trial in Parkinson’s disease. An important feature is that we have values of responses and five potential prognostic factors from a sample of 144 patients similar to those to be enrolled in the trial. Analysis of this sample provides a model for trial analysis. The comparison of allocation rules is made by simulation yielding measures of loss due to imbalance and of potential bias. A major novelty of the paper is the use of this sample, via a two-stage algorithm, to provide an empirical distribution of covariates for the simulation; sampling of a correlated multivariate normal distribution is followed by transformation to variables following the empirical marginal distributions. Six allocation rules are evaluated. The paper concludes with some comments on general aspects of the evaluation of such rules and provides a recommendation for two allocation rules, one for each site, depending on the target number of patients to be enrolled.

Item Type: Article
Additional Information: © 2023 The Author(s).
Divisions: Statistics
Subjects: H Social Sciences > HA Statistics
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Date Deposited: 18 Apr 2023 09:24
Last Modified: 15 Apr 2024 20:06

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