Main and moderated effects of multimorbidity and depressive symptoms on cognition

de Araujo, Jacyra Azevedo Paiva, Xavier, Érika Fialho Morais, Rodrigues, Elisângela da Silva, Machado, Daiane Borges, Barreto, Marcos E. ORCID: 0000-0002-7818-1855, Kanaan, Richard A., Barreto, Mauricio L. and Castro-De-araujo, Luis Fernando Silva (2022) Main and moderated effects of multimorbidity and depressive symptoms on cognition. Brazilian Journal of Psychiatry, 44 (6). 644 - 649. ISSN 1516-4446

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Abstract

OBJECTIVE: Multimorbidity, or the occurrence of two or more chronic conditions, is a global challenge, with implications for mortality, morbidity, disability, and life quality. Psychiatric disorders are common among the chronic diseases that affect patients with multimorbidity. It is still not well understood whether psychiatric symptoms, especially depressive symptoms, moderate the effect of multimorbidity on cognition. METHODS: We used a large (n=2,681) dataset to assess whether depressive symptomatology moderates the effect of multimorbidity on cognition using structural equation modelling. RESULTS: It was found that the more depressive symptoms and chronic conditions, the worse the cognitive performance, and the higher the educational level, the better the cognitive performance. We found a significant but weak (0.009; p = 0.04) moderating effect. CONCLUSION: We have provided the first estimate of the moderating effect of depression on the relation between multimorbidity and cognition, which was small. Although this moderation has been implied by many previous studies, it was never previously estimated.

Item Type:	Article
Official URL:	https://www.bjp.org.br/
Additional Information:	© 2022, Associacao Brasileira de Psiquiatria.
Divisions:	Statistics
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Date Deposited:	06 Jan 2023 15:18
Last Modified:	20 Dec 2024 00:47
URI:	http://eprints.lse.ac.uk/id/eprint/117776

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