Cookies?
Library Header Image
LSE Research Online LSE Library Services

Budget impact analysis of Dalbavancin in the treatment of acute bacterial skin and skin structure infections in three European countries

Marcellusi, Andrea, Bini, Chiara, Andreoni, Massimo, Sarmati, Loredana, Espin, Jaime, Horcajada, Juan P., Czypionka, Thomas, Andretta, Davide, Sciattella, Paolo, Favato, Giampiero and Mennini, Francesco S. (2020) Budget impact analysis of Dalbavancin in the treatment of acute bacterial skin and skin structure infections in three European countries. Clinical Drug Investigation, 40 (4). pp. 305-318. ISSN 1173-2563

Full text not available from this repository.
Identification Number: 10.1007/s40261-020-00891-w

Abstract

Background and Objective: Acute bacterial skin and skin structure infections (ABSSSIs) have been defined by the US Food and Drug Administration (FDA) in 2013 to include a subset of complicated skin and skin structure infections commonly treated with parenteral antibiotic therapy. Inpatient treatment of ABSSSIs involves a significant economic burden on the healthcare system. This study aimed to evaluate the economic impact on the National Health System associated with the management of non-severe ABSSSIs treated in hospitals with innovative long-acting dalbavancin compared to standard antibiotic therapy in Italy, Spain, and Austria. Methods: A budget impact analysis was developed to evaluate the direct costs associated with the management of ABSSSI from the national public health system perspective. The model considered the possibility of early discharge of patients directly from the Emergency Department (ED), after 1 night in the hospital, or after two or three nights in the hospital. A scenario with Standard of Care was compared with a dalbavancin scenario, where patients had the possibility of being discharged early. The epidemiological and cost parameters were extrapolated from national administrative databases and from a systematic literature review for each country. The analysis was conducted in a 3-year time horizon. A one-way deterministic sensitivity analysis was conducted to examine the robustness of the results. Results: The model estimated an average annual number of patients with non-severe ABSSSI in Italy, Spain, and Austria equal to 5396, 7884, and 1788, respectively. A total annual expenditure of about €9.9 million, €13.5 million, and €3.4 million was estimated for treating the full set of ABSSSI patients in Italy, Spain, and Austria, respectively. Dalbavancin reduced the in-hospital length of stay in each country. In the first year of its introduction, dalbavancin significantly reduced the total economic burden in Italy and Spain (− €352,252 and − €233,991, respectively), while it increased the total economic burden in Austria (€80,769, 0.7% of the total expenditure for these patients); in the third year of its introduction, dalbavancin reduced the total economic burden in each Country (− €1.1 million, − €810,650, and − €70,269, respectively). Conclusions: The introduction of dalbavancin in a new patient pathway to treat non-severe ABSSSI could generate a significant reduction in hospitalized patients and the overall patient length of stay in hospital.

Item Type: Article
Additional Information: © 2020, Springer Nature Switzerland AG.
Divisions: LSE
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Date Deposited: 13 Sep 2022 16:12
Last Modified: 13 Sep 2022 16:12
URI: http://eprints.lse.ac.uk/id/eprint/116607

Actions (login required)

View Item View Item