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Evaluating Montreál's harm reduction interventions for people who inject drugs: protocol for observational study and cost-effectiveness analysis

Panagiotoglou, Dimitra, Abrahamowicz, Michal, Buckeridge, David L., Caro, J. Jaime, Latimer, Eric, Maheu-Giroux, Mathieu and Strumpf, Erin C. (2021) Evaluating Montreál's harm reduction interventions for people who inject drugs: protocol for observational study and cost-effectiveness analysis. BMJ Open, 11 (10). ISSN 2044-6055

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Identification Number: 10.1136/bmjopen-2021-053191


Introduction The main harm reduction interventions for people who inject drugs (PWID) are supervised injection facilities, needle and syringe programmes and opioid agonist treatment. Current evidence supporting their implementation and operation underestimates their usefulness by excluding skin, soft tissue and vascular infections (SSTVIs) and anoxic/toxicity-related brain injury from cost-effectiveness analyses (CEA). Our goal is to conduct a comprehensive CEA of harm reduction interventions in a setting with a large, dispersed, heterogeneous population of PWID, and include prevention of SSTVIs and anoxic/toxicity-related brain injury as measures of benefit in addition to HIV, hepatitis C and overdose morbidity and mortalities averted. Methods and analysis This protocol describes how we will develop an open, retrospective cohort of adult PWID living in Québec between 1 January 2009 and 31 December 2020 using administrative health record data. By complementing this data with non-linkable paramedic dispatch records, regional monthly needle and syringe dispensation counts and repeated cross-sectional biobehavioural surveys, we will estimate the hazards of occurrence and the impact of Montreál's harm reduction interventions on the incidence of drug-use-related injuries, infections and deaths. We will synthesise results from our empirical analyses with published evidence to simulate infections and injuries in a hypothetical population of PWID in Montreál under different intervention scenarios including current levels of use and scale-up, and assess the cost-effectiveness of each intervention from the public healthcare payer's perspective. Ethics and dissemination This study was approved by McGill University's Institutional Review Board (Study Number: A08-E53-19B). We will work with community partners to disseminate results to the public and scientific community via scientific conferences, a publicly accessible report, op-ed articles and open access peer-reviewed journals.

Item Type: Article
Official URL:
Additional Information: © 2021 The Authors
Divisions: Hellenic Observatory
Subjects: H Social Sciences > HV Social pathology. Social and public welfare. Criminology
R Medicine > RA Public aspects of medicine
Date Deposited: 17 Nov 2021 14:45
Last Modified: 31 May 2024 02:15

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