Cookies?
Library Header Image
LSE Research Online LSE Library Services

Telomere length and epigenetic age acceleration in adolescents with anxiety disorders

Cerveira de Baumont, Angelica, Hoffmann, Mauricio Scopel, Bortoluzzi, Andressa, Fries, Gabriel R., Lavandoski, Patrícia, Grun, Lucas K., Guimarães, Luciano S.P., Guma, Fátima T.C.R., Salum, Giovanni Abrahão, Barbé-Tuana, Florencia M. and Manfro, Gisele G. (2021) Telomere length and epigenetic age acceleration in adolescents with anxiety disorders. Scientific Reports, 11 (1). ISSN 2045-2322

[img] Text (s41598-021-87045-w) - Published Version
Available under License Creative Commons Attribution.

Download (1MB)
Identification Number: 10.1038/s41598-021-87045-w

Abstract

Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life.

Item Type: Article
Official URL: https://www.nature.com/srep/
Additional Information: This study was supported by grants from the CNPq (483032/2007-7, 305524/2009-7, 476366/2009-7), FIPE-HCPA (12-0254, 15-0349), FAPERGS/ PRONEX (10/0018-3) and FAPERGS/PRONEM (11/2043-0). Mauricio Scopel Hoffmann is supported by the research grant of the Brazilian Ministry of Health under the “Termo De Execução Descentralizada—TED 12/2019”. Giovanni Abrahão Salum is supported by the US National Institute of Mental Health (Grant number R01MH120482). Gisele G Manfro received a Brazilian Council of Research CNPq senior scholarship (306249/2017-0). © 2021 The Authors
Divisions: Personal Social Services Research Unit
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
H Social Sciences > HQ The family. Marriage. Woman
Date Deposited: 12 Oct 2021 23:13
Last Modified: 14 Oct 2021 07:48
URI: http://eprints.lse.ac.uk/id/eprint/112417

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics