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Preference-based instrumental variables in health research rely on important and underreported assumptions: a systematic review

Widding-havneraas, Tarjei, Chaulagain, Ashmita, Lyhmann, Ingvild, Zachrisson, Henrik Daae, Elwert, Felix, Markussen, Simen, Mcdaid, David ORCID: 0000-0003-0744-2664 and Mykletun, Arnstein (2021) Preference-based instrumental variables in health research rely on important and underreported assumptions: a systematic review. Journal of Clinical Epidemiology. ISSN 0895-4356

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Identification Number: 10.1016/j.jclinepi.2021.06.006

Abstract

Objective: Preference-based instrumental variables (PP IV) designs can identify causal effects when patients receive treatment due to variation in providers’ treatment preference. We offer a systematic review and methodological assessment of PP IV applications in health research. Study Design and Setting: We included studies that applied PP IV for evaluation of any treatment in any population in health research (PROSPERO: CRD42020165014). We searched within four databases (Medline, Web of Science, ScienceDirect, SpringerLink) and four journals (including full-text and title and abstract sources) between January 1, 1998, and March 5, 2020. We extracted data on areas of applications and methodology, including assumptions using Swanson and Hernan’s (2013) guideline. Results: We included 185 of 1087 identified studies. The use of PP IV has increased, being predominantly used for treatment effects in cancer, cardiovascular disease, and mental health. The most common PP IV was treatment variation at the facility-level, followed by physician- and regional-level. Only 12 percent of applications report the four main assumptions for PP IV. Selection on treatment may be a potential issue in 46 percent of studies. Conclusion: The assumptions of PP IV are not sufficiently reported in existing work. PP IV studies should use reporting guidelines.

Item Type: Article
Official URL: https://www.jclinepi.com/
Additional Information: © 2021 The Authors
Divisions: Personal Social Services Research Unit
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > R Medicine (General)
Date Deposited: 21 Jul 2021 10:51
Last Modified: 20 Sep 2021 04:14
URI: http://eprints.lse.ac.uk/id/eprint/111066

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