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A systematic review and critical assessment of incentive strategies for discovery and development of novel antibiotics

Renwick, Matthew, Brogan, David M. and Mossialos, Elias (2015) A systematic review and critical assessment of incentive strategies for discovery and development of novel antibiotics. Journal of Antibiotics, 69. pp. 73-88. ISSN 0021-8820

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Identification Number: 10.1038/ja.2015.98

Abstract

Despite the growing threat of antimicrobial resistance, pharmaceutical and biotechnology firms are reluctant to develop novel antibiotics because of a host of market failures. This problem is complicated by public health goals that demand antibiotic conservation and equitable patient access. Thus, an innovative incentive strategy is needed to encourage sustainable investment in antibiotics. This systematic review consolidates, classifies and critically assesses a total of 47 proposed incentives. Given the large number of possible strategies, a decision framework is presented to assist with the selection of incentives. This framework focuses on addressing market failures that result in limited investment, public health priorities regarding antibiotic stewardship and patient access, and implementation constraints and operational realities. The flexible nature of this framework allows policy makers to tailor an antibiotic incentive package that suits a country’s health system structure and needs.

Item Type: Article
Official URL: http://www.nature.com/ja/index.html
Additional Information: © 2015 Japan Antibiotics Research Association
Divisions: LSE
Subjects: R Medicine > RA Public aspects of medicine
Sets: Research centres and groups > LSE Health and Social Care
Date Deposited: 07 Jan 2016 10:04
Last Modified: 20 Jul 2019 02:04
Funders: Economic and Social Research Council
URI: http://eprints.lse.ac.uk/id/eprint/64852

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