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Cost-effectiveness of adherence therapy versus health education for people with schizophrenia: randomised controlled trial in four European countries

Patel, Anita, McCrone, Paul, Leese, Morven, Amaddeo, Francesco, Tansella, Michele, Kilian, Reinhold, Angermeyer, Matthias, Kikkert, Martijn, Schene, Aart and Knapp, Martin ORCID: 0000-0003-1427-0215 (2013) Cost-effectiveness of adherence therapy versus health education for people with schizophrenia: randomised controlled trial in four European countries. Cost Effectiveness and Resource Allocation, 11 (1). p. 12. ISSN 1478-7547

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Identification Number: 10.1186/1478-7547-11-12

Abstract

Background: Non-adherence to anti-psychotics is common, expensive and affects recovery. We therefore examine the cost-effectiveness of adherence therapy for people with schizophrenia by multi-centre randomised trial in Amsterdam, London, Leipzig and Verona. Methods: Participants received 8 sessions of adherence therapy or health education. We measured lost productivity and use of health/social care, criminal justice system and informal care at baseline and one year to estimate and compare mean total costs from health/social care and societal perspectives. Outcomes were the Short Form 36 (SF-36) mental component score (MCS) and quality-adjusted life years (QALYs) gained (SF-36 and EuroQoL 5 dimension (EQ5D)). Cost-effectiveness was examined for all cost and outcome combinations using cost-effectiveness acceptability curves (CEACs). Results: 409 participants were recruited. There were no cost or outcome differences between adherence therapy and health education. The probability of adherence therapy being cost-effective compared to health education was between 0.3 and 0.6 for the six cost-outcome combinations at the willingness to pay thresholds we examined. Conclusions: Adherence therapy appears equivalent to health education. It is unclear whether it would have performed differently against a treatment as usual control, whether such an intervention can impact on quality of life in the short-term, or whether it is likely to be cost-effective in some sites but not others.

Item Type: Article
Official URL: http://www.resource-allocation.com/
Additional Information: © 2013 The Authors
Divisions: Personal Social Services Research Unit
Subjects: R Medicine > RA Public aspects of medicine
Sets: Research centres and groups > Personal Social Services Research Unit (PSSRU)
Date Deposited: 07 Sep 2015 16:21
Last Modified: 20 Jan 2020 05:14
Projects: QLG4-CT-2001-01734
Funders: Quality of Life and Management of Living Resources Programme
URI: http://eprints.lse.ac.uk/id/eprint/63446

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