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Cost-effectiveness of hepatitis A vaccination for adults in Belgium

Luyten, Jeroen, Van de Sande, Stefaan, De Schrijver, Koen, Van Damme, Pierre and Beutels, Philippe (2012) Cost-effectiveness of hepatitis A vaccination for adults in Belgium. Vaccine, 30 (42). pp. 6070-6080. ISSN 0264-410X

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Identification Number: 10.1016/j.vaccine.2012.07.049


Hepatitis A vaccination targeting adults (or adult risk-groups like e.g. travellers, health care workers, soldiers or teachers) could be considered an alternative to a universal infant or adolescent vaccination program in low endemic countries. We estimated the current disease burden of hepatitis A in Belgium, and evaluated whether adult vaccination is cost-effective. We used a Markov cohort model to simulate the costs and effects of (1) vaccination of adults and (2) serological screening of adults and vaccination of susceptibles and compared these with the current situation. The results indicated that these expanded vaccination strategies are not cost-effective in the epidemiological circumstances of a typical low-endemic western country. In order to gain 1 quality-adjusted life year the health care payer would have to pay 185,000€ for vaccination and 223,000€ for screening and vaccination of seronegatives. For adult vaccination to be cost-effective, risk-groups would need to be exposed to a force of infection that is 3.5–4 times higher than currently estimated in the general population; or the total costs of vaccination would have to drop with approximately 75%.

Item Type: Article
Official URL:
Additional Information: © 2012 Elsevier Ltd
Divisions: Social Policy
Subjects: H Social Sciences > HC Economic History and Conditions
H Social Sciences > HV Social pathology. Social and public welfare. Criminology
R Medicine > RA Public aspects of medicine
R Medicine > RS Pharmacy and materia medica
Date Deposited: 10 Oct 2014 16:04
Last Modified: 17 Jul 2024 02:27
Projects: SIMID (IWT 060081)
Funders: Belgian Health Care Knowledge Centre, Innovation by Science and Technology in Flanders

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