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Symptomatic remission and patient quality of life in an observational study of schizophrenia: is there a relationship?

Haro, Josep M., Novick, Diego, Perrin, Elena, Bertsch, Jordan and Knapp, Martin ORCID: 0000-0003-1427-0215 (2014) Symptomatic remission and patient quality of life in an observational study of schizophrenia: is there a relationship? Psychiatry Research, 220 (1-2). pp. 163-169. ISSN 0165-1781

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Identification Number: 10.1016/j.psychres.2014.07.034


This analysis aimed to examine the association between remission and quality of life (QOL) in schizophrenia. In post-hoc analyses of the 3-year, prospective, observational Schizophrenia Outpatients Health Outcomes (SOHO) study, we compared the QOL of patients who achieved symptomatic and clinical remission with those who did not, and the factors associated. Symptomatic remission was defined as achieving a score of ≤3 on the Clinical Global Impression-Schizophrenia (CGI-SCH) scale, maintained for 6 months and without hospitalization. QOL was patient self-rated using the European-QOL. Of the 6516 patients analyzed, 38% were in symptomatic remission 12 months post-baseline and 52% at 36 months. Functional remission remained fairly constant from 12 months to 36 months (22.4% at both time points). At all visits from 12 to 36 months, patient QOL and social functioning were significantly higher for patients in symptomatic remission. QOL was higher in patients in functional remission. Patients with maintained symptomatic remission over the 3-year follow-up had a much greater improvement in QOL than patients with no symptomatic remission or symptomatic remission for part of the period. Factors associated with a better QOL also included paid employment, socially active, a higher CGI-SCH cognitive score, good compliance, and a better baseline QOL.

Item Type: Article
Official URL:
Additional Information: © 2014 Elsevier Ireland Ltd.
Divisions: Social Policy
Personal Social Services Research Unit
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Sets: Departments > Social Policy
Research centres and groups > Personal Social Services Research Unit (PSSRU)
Research centres and groups > NIHR School for Social Care Research
Date Deposited: 25 Sep 2014 10:49
Last Modified: 20 Sep 2021 03:48
Funders: Eli Lilly and Company

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