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Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)

Clare, Linda and Bayer, Antony and Burns, Alistair and Corbett, Anne and Jones, Roy and Knapp, Martin and Kopelman, Michael and Kudlicka, Aleksandra and Leroi, Iracema and Oyebode, Jan and Pool, Jackie and Woods, Bob and Whitaker, Rhiannon (2013) Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials, 14 (1). p. 152. ISSN 1745-6215

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Identification Number: 10.1186/1745-6215-14-152

Abstract

Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer’s disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers. Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined. Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion. Trial registration: Current Controlled Trials ISRCTN21027481

Item Type: Article
Official URL: http://www.trialsjournal.com/
Additional Information: © 2013 The Authors
Subjects: R Medicine > RA Public aspects of medicine
Sets: Departments > Social Policy
Research centres and groups > Personal Social Services Research Unit (PSSRU)
Research centres and groups > LSE Health
Research centres and groups > NIHR School for Social Care Research
Date Deposited: 03 Apr 2014 13:42
Last Modified: 18 Jun 2014 12:59
Funders: National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme
URI: http://eprints.lse.ac.uk/id/eprint/56388

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