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Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)

Clare, Linda, Bayer, Antony, Burns, Alistair, Corbett, Anne, Jones, Roy, Knapp, Martin ORCID: 0000-0003-1427-0215, Kopelman, Michael, Kudlicka, Aleksandra, Leroi, Iracema, Oyebode, Jan, Pool, Jackie, Woods, Bob and Whitaker, Rhiannon (2013) Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials, 14 (1). p. 152. ISSN 1745-6215

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Identification Number: 10.1186/1745-6215-14-152

Abstract

Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer’s disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers. Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined. Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion. Trial registration: Current Controlled Trials ISRCTN21027481

Item Type: Article
Official URL: http://www.trialsjournal.com/
Additional Information: © 2013 The Authors
Divisions: Social Policy
Personal Social Services Research Unit
LSE Health
Subjects: R Medicine > RA Public aspects of medicine
Sets: Departments > Social Policy
Research centres and groups > Personal Social Services Research Unit (PSSRU)
Research centres and groups > LSE Health
Research centres and groups > NIHR School for Social Care Research
Date Deposited: 03 Apr 2014 13:42
Last Modified: 20 May 2020 02:52
Funders: National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme
URI: http://eprints.lse.ac.uk/id/eprint/56388

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