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Early life exposure to the 1918 influenza pandemic and old-age mortality by cause of death

Myrskylä, Mikko, Mehta, Neil K and Chang, Virginia W. (2013) Early life exposure to the 1918 influenza pandemic and old-age mortality by cause of death. American Journal of Public Health, 103 (7). e83-e90. ISSN 0090-0036

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Abstract

Objectives. We sought to analyze how early exposure to the 1918 influenza pandemic is associated with old-age mortality by cause of death. Methods. We analyzed the National Health Interview Survey (n = 81 571; follow-up 1989–2006; 43 808 deaths) and used year and quarter of birth to assess timing of pandemic exposure. We used Cox proportional and Fine-Gray competing hazard models for all-cause and cause-specific mortality, respectively. Results. Cohorts born during pandemic peaks had excess all-cause mortality attributed to increased noncancer mortality. We found evidence for a trade-off between noncancer and cancer causes: cohorts with high noncancer mortality had low cancer mortality, and vice versa. Conclusions. Early disease exposure increases old-age mortality through noncancer causes, which include respiratory and cardiovascular diseases, and may trigger a trade-off in the risk of cancer and noncancer causes. Potential mechanisms include inflammation or apoptosis. The findings contribute to our understanding of the causes of death behind the early disease exposure–later mortality association. The cancer–noncancer trade-off is potentially important for understanding the mechanisms behind these associations.

Item Type: Article
Official URL: http://dx.doi.org/10.2105/AJPH.2012.301060
Additional Information: © 2013 American Public Health Association
Library of Congress subject classification: H Social Sciences > HN Social history and conditions. Social problems. Social reform
Sets: Departments > Social Policy
Rights: http://www.lse.ac.uk/library/usingTheLibrary/academicSupport/OA/depositYourResearch.aspx
Identification Number: http://ajph.aphapublications.org/
Funders: Robert Wood Johnson Foundation Health & Society Scholars Program
Date Deposited: 24 Oct 2013 15:48
URL: http://eprints.lse.ac.uk/53781/

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