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Symptomatic vitreomacular adhesion

Jackson, Timothy, Nicod, Elena, Simpson, Andrew, Angelis, Aris ORCID: 0000-0002-0261-4634, Grimaccia, Federico and Kanavos, Panos ORCID: 0000-0001-9518-3089 (2013) Symptomatic vitreomacular adhesion. Retina, 33 (8). pp. 1503-1511. ISSN 1539-2864

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Identification Number: 10.1097/IAE.0b013e31829232fd


Background: Symptomatic vitreomacular adhesion describes symptomatic loss of visual function as a result of vitreous traction at the macula. Methods: Literature review. Results: Symptomatic vitreomacular adhesion can occur in isolation as vitreomacular traction, which may lead to the development of a macular hole, or it may occur alongside epiretinal membrane. It is likely to be associated with age-related macular degeneration and possibly diabetic maculopathy, although this is less certain. The treatment depends largely on the cause, but options include observation, vitrectomy, and pharmacologic vitreolysis. Small uncontrolled trials have also explored the use of an intravitreal gas bubble as a means of releasing VMA. If all cases of sVMA are considered together, then the burden of illness is substantial, with a prevalence of ∼0.35 per 100 population (excluding epiretinal membrane). Furthermore, there may be many more cases of undiagnosed sVMA. Conclusion: The recent introduction of ocriplasmin is likely to increase interest in sVMA. Clinical trials suggest that it has a role in the treatment of vitreomacular traction and Stages 1 to 3 macular holes but not primarily as a treatment of epiretinal membrane. Its role in other diseases associated with VMA remains to be determined.

Item Type: Article
Official URL:
Additional Information: © 2013 Ophthalmic Communications Society
Divisions: European Institute
Social Policy
LSE Health
Subjects: R Medicine > RE Ophthalmology
Date Deposited: 23 Sep 2013 09:34
Last Modified: 20 Oct 2021 00:29

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