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Vitreous attachment in age-related macular degeneration, diabetic macular edema, and retinal vein occlusion

Jackson, Timothy L., Nicod, Elena, Angelis, Aris ORCID: 0000-0002-0261-4634, Grimaccia, Federico, Prevost, Toby, Simpson, Andrew and Kanavos, Panos ORCID: 0000-0001-9518-3089 (2013) Vitreous attachment in age-related macular degeneration, diabetic macular edema, and retinal vein occlusion. Retina, 33 (6). pp. 1099-1108. ISSN 1539-2864

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Identification Number: 10.1097/IAE.0b013e31828991d6

Abstract

To determine if there is an association of vitreous attachment and wet age-related macular degeneration (AMD), diabetic macular edema, and retinal vein occlusion. METHODS:: Systematic review and metaanalysis. RESULTS:: Sixteen of 1,025 articles were eligible. In wet AMD, the prevalence of vitreomacular adhesion and posterior vitreous detachment was 23% (654 eyes) and 41% (251), respectively. Vitreomacular adhesion prevalence was 2.15 times that of controls (95% confidence interval, 1.34-3.48; p = 0.002) and 2.54 times that of dry AMD (confidence interval, 0.88-7.36; p 0.09); posterior vitreous detachment prevalence was lower than controls (relative risk 0.77; confidence interval, 0.64-0.93; p = 0.007) and dry AMD (0.56; confidence interval, 0.27-1.14; p = 0.11). It was not possible to determine the prevalence of vitreous attachment in diabetic macular edema, but vitreomacular traction was present in 29% of 188 surgical cases. The prevalence of posterior vitreous detachment in eyes with central and branch retinal vein occlusion was 30% (56 eyes) and 31% (71 eyes), respectively, versus 25% (64 eyes) in controls. CONCLUSION:: Observational studies of sufficient quality indicate that eyes with wet AMD have double the expected prevalence of vitreomacular adhesion and are less likely to have a posterior vitreous detachment. More controlled studies of diabetic macular edema and retinal vein occlusion are needed.

Item Type: Article
Official URL: http://journals.lww.com/retinajournal/pages/defaul...
Additional Information: © 2013 Ophthalmic Communications Society,
Divisions: European Institute
Social Policy
LSE Health
Subjects: R Medicine > R Medicine (General)
Sets: Departments > European Institute
Departments > Social Policy
Research centres and groups > LSE Health and Social Care
Research centres and groups > LSE Health
Date Deposited: 22 Mar 2013 15:44
Last Modified: 20 Oct 2020 03:48
URI: http://eprints.lse.ac.uk/id/eprint/49378

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