Atkinson, Anthony C. (2012) Optimum experimental designs for choosing between competitive and non competitive models of enzyme inhibition. Communications in statistics: theory and methods, 41 (13-14). pp. 2283-2296. ISSN 0361-0926
In the study of the inhibition of enzyme reactions the Michaelis-Menten model is extended to include two experimental variables and three or more parameters. We combine the three-parameter models for competitive and non competitive inhibition in a four-parameter model and use optimum design theory to find D-and Ds-optimum designs for discriminating between the models. These designs are compared with compound T-optimum designs which provide the most powerful tests for discrimination between models. A single design is found with high discrimination efficiency whichever model is true.
|Additional Information:||© 2012 Taylor and Francis Group, LLC.|
|Uncontrolled Keywords:||combined model, cmparable parameters, compound T-optimality, Ds-optimality, general equivalence theorem, model-building|
|Library of Congress subject classification:||H Social Sciences > HA Statistics|
|Sets:||Departments > Statistics|
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