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Optimum experimental designs for choosing between competitive and non competitive models of enzyme inhibition

Atkinson, Anthony C. (2012) Optimum experimental designs for choosing between competitive and non competitive models of enzyme inhibition. Communications in Statistics: Theory and Methods, 41 (13-14). pp. 2283-2296. ISSN 0361-0926

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Abstract

In the study of the inhibition of enzyme reactions the Michaelis-Menten model is extended to include two experimental variables and three or more parameters. We combine the three-parameter models for competitive and non competitive inhibition in a four-parameter model and use optimum design theory to find D-and Ds-optimum designs for discriminating between the models. These designs are compared with compound T-optimum designs which provide the most powerful tests for discrimination between models. A single design is found with high discrimination efficiency whichever model is true.

Item Type: Article
Official URL: http://www.tandfonline.com/action/aboutThisJournal...
Additional Information: © 2012 Taylor and Francis Group, LLC.
Library of Congress subject classification: H Social Sciences > HA Statistics
Sets: Departments > Statistics
Rights: http://www.lse.ac.uk/library/usingTheLibrary/academicSupport/OA/depositYourResearch.aspx
Date Deposited: 02 Jul 2012 13:38
URL: http://eprints.lse.ac.uk/44571/

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