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An economic evaluation of universal vaccination against Hepatitis B virus

McGuire, Alistair, Fenn, Paul and Gray, Alistair (1996) An economic evaluation of universal vaccination against Hepatitis B virus. Journal of Infection, 32 (3). pp. 197-204. ISSN 0163-4453

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Identification Number: 10.1016/S0163-4453(96)80019-3


This report presents the results of an economic evaluation utilizing U.K. data, into a vaccination programme against Hepatitis B using a genetically engineered, yeast-derived vaccine, Engerix B. Cost-effectiveness ratios were calculated for four different programmes: an infant vaccination programme; a child vaccination programme; an adolescent vaccination programme; and a combined child and adolescent programme. For each programme, the number of annual cohorts vaccinated was varied from 1 to 25. The outcome was defined as incremental life years gained, and the results are reported as costs per incremental life-year gained. Benefits were calculated in both undiscounted and discounted forms. All costs were discounted. The discount rate used was 6%. All major epidemiological and cost assumptions were subjected to a sensitivity analysis. Baseline results with benefits discounted range from £188 015 to £301 365 per life year gained, depending on the duration of programme and vaccination strategy. With benefits undiscounted, the comparable range is from £5234 to £13 034.

Item Type: Article
Official URL:
Additional Information: © 1996 Elsevier Ltd.
Divisions: Social Policy
LSE Health
Subjects: R Medicine > RA Public aspects of medicine
Date Deposited: 06 Feb 2009 14:15
Last Modified: 21 Feb 2024 07:36

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