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Modelling the impact of clozapine on suicide in patients with treatment-resistant schizophrenia in the UK

Duggan, Andy, Warner, Juliet, Knapp, Martin and Kerwin, Robert (2003) Modelling the impact of clozapine on suicide in patients with treatment-resistant schizophrenia in the UK. British Journal of Psychiatry, 182 (6). pp. 505-508. ISSN 0007-1250

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Abstract

Background: Schizophrenia is a major cause of suicide, and symptoms characteristic of treatment-resistant disease are strong risk factors. Clozapine reduces symptoms in 60% of such patients and significantly decreases the risk of suicide. Aims: To model the impact of increased clozapine prescribing on lives saved and resource utilisation. Method: A model was built to compare current levels of clozapine prescribing with a scenario in which all suitable patients with treatment-resistant schizophrenia received clozapine. Results: It was estimated that an average of 53 lives could be saved in the UK each year. If clozapine is cost-neutral, the cost per life-year saved is £5108. If clozapine achieves a 10% reduction in annual support costs, the net saving is £8.7 million per annum. An average of 167 acute beds would be freed each year. Conclusions: The use of clozapine in treatment-resistant schizophrenia saves lives, frees resources and is cost-effective.

Item Type: Article
Official URL: http://bjp.rcpsych.org
Additional Information: © 2003 Royal College of Psychiatrists
Library of Congress subject classification: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Sets: Departments > Social Policy
Research centres and groups > Personal Social Services Research Unit (PSSRU)
Research centres and groups > LSE Health
Research centres and groups > NIHR School for Social Care Research
Rights: http://www.lse.ac.uk/library/usingTheLibrary/academicSupport/OA/depositYourResearch.aspx
Date Deposited: 05 Sep 2008 13:41
URL: http://eprints.lse.ac.uk/18120/

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