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Modelling the impact of clozapine on suicide in patients with treatment-resistant schizophrenia in the UK

Duggan, Andy, Warner, Juliet, Knapp, Martin ORCID: 0000-0003-1427-0215 and Kerwin, Robert (2003) Modelling the impact of clozapine on suicide in patients with treatment-resistant schizophrenia in the UK. British Journal of Psychiatry, 182 (6). pp. 505-508. ISSN 0007-1250

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Identification Number: 10.1192/02-538

Abstract

Background: Schizophrenia is a major cause of suicide, and symptoms characteristic of treatment-resistant disease are strong risk factors. Clozapine reduces symptoms in 60% of such patients and significantly decreases the risk of suicide. Aims: To model the impact of increased clozapine prescribing on lives saved and resource utilisation. Method: A model was built to compare current levels of clozapine prescribing with a scenario in which all suitable patients with treatment-resistant schizophrenia received clozapine. Results: It was estimated that an average of 53 lives could be saved in the UK each year. If clozapine is cost-neutral, the cost per life-year saved is £5108. If clozapine achieves a 10% reduction in annual support costs, the net saving is £8.7 million per annum. An average of 167 acute beds would be freed each year. Conclusions: The use of clozapine in treatment-resistant schizophrenia saves lives, frees resources and is cost-effective.

Item Type: Article
Official URL: http://bjp.rcpsych.org
Additional Information: © 2003 Royal College of Psychiatrists
Divisions: Social Policy
Personal Social Services Research Unit
LSE Health
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Date Deposited: 05 Sep 2008 13:41
Last Modified: 03 Jan 2024 23:09
URI: http://eprints.lse.ac.uk/id/eprint/18120

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