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Non-adherence to antipsychotic medication regimens: associations with resource use and costs

Knapp, Martin ORCID: 0000-0003-1427-0215, King, Derek ORCID: 0000-0002-2408-4558, Pugner, Klaus and Lapuerta, Pablo (2004) Non-adherence to antipsychotic medication regimens: associations with resource use and costs. British Journal of Psychiatry, 184 (6). pp. 509-516. ISSN 0007-1250

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Identification Number: 10.1192/bjp.184.6.509


Background: Several factors are thought to influence resource use and costs in treating schizophrenia. Aims: To assess the relative impact of non-adherence and other factors associated with resource use and costs incurred by people with schizophrenia. Method: Secondary analyses were made of data from a 1994 national survey of psychiatric morbidity among adults living in institutions in the UK. Factors potentially relating to resource use and costs were examined using two-part models. Results: Patients who failed to adhere to their medication regimen were over one-and-a-half times as likely as patients who did adhere to it to report use of in-patient services. Non-adherence is one of the most significant factors in increasing external service costs, by a factor of almost 3. Non-adherence predicted an excess annual cost per patient of approximately £2500 for in-patient services and over £5000 for total service use. Conclusions: Resource use and costs are influenced by various factors. Medication non-adherence consistently exhibits an association with higher costs. Further important factors are patient needs and the ability of the system to address them.

Item Type: Article
Official URL:
Additional Information: © 2004 Royal College of Psychiatrists
Divisions: Social Policy
Personal Social Services Research Unit
LSE Health
Subjects: H Social Sciences > HC Economic History and Conditions
R Medicine > RM Therapeutics. Pharmacology
JEL classification: I - Health, Education, and Welfare > I1 - Health > I12 - Health Production: Nutrition, Mortality, Morbidity, Suicide, Substance Abuse and Addiction, Disability, and Economic Behavior
Date Deposited: 05 Sep 2008 13:55
Last Modified: 16 May 2024 00:13

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